2017 Fiscal Year Final Research Report
Exploration of methionine uptake mechanism on glioma through microRNA analysis
| Project/Area Number |
16K19991
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Research Collaborator |
ISHI Yukitomo 北海道大学, 医学院, 大学院生
KO Suken 北海道大学, 医学院, 大学院生
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | gene expression analysis |
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| Outline of Final Research Achievements |
Gliomas usually show high uptake of methionine in Positron Emission Tomography, but the mechanism of methionine uptake remain unknown. We explored these mechanism through gene expression analysis including microRNA. At the same time, we also investigated the correlation between various somatic mutations of gliomas and clinical information, such as intraoperative fluorescence status of phododynamic diagnosis, MRI appearance, and prognosis using gene expression analysis. In result, we could not identify the specific molecule in methionine uptake of glioma, but we could identify potentially important two molecules in gliomas; 1) PEPT2, which may have important role in the intratumoral fluorescence in glioma photodynamic diagnosis using 5-ALA, and 2) CDKN2A, which may be one of the key gene of the prognosis on glioma with BRAF somatic mutation.
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| Free Research Field |
脳腫瘍学
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