The effect of transcription factor Nrf2 on EBI after subarachnoid hemorrhage

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19997
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Kanazawa University
• Principal Investigator: Aida Yasuhiro 金沢大学, 医学系, 協力研究員 (50735438)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: くも膜下出血 / 早期脳損傷 / 酸化ストレス

Outline of Final Research Achievements

Early brain injury (EBI) mainly focusing on cerebral edema and cytotoxicity changes occurred within 72 hours after bleeding, instead of cerebral vasospasm, has been noted as a factor that regulates the prognosis of subarachnoid hemorrhage. To clarify an oxidative stress and Nrf2, which is oxidative stress response regulatory transcription factor, is involved in EBI, we conducted animal experiments using a blood vessel penetration model in rats and mice, and we got the results that both were related. Targeting Nrf2, we would like to lead to the prognostic prediction after subarachnoid hemorrhage and the establishment of treatment and therapeutic effect judgment on EBI.

Free Research Field

脳神経外科学