Improvement of cognitive function by pallidal border cell stimulation in Parkinson DIsease

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20020
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Yokohama City University
• Principal Investigator: Kimura Katsuo 横浜市立大学, 附属市民総合医療センター, 助教 (60438140)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: パーキンソン病 / 脳深部刺激療法 / 淡蒼球 / 境界細胞

Outline of Final Research Achievements

Deep brain stimulation therapy (DBS) is an established treatment for patients with advanced Parkinson's disease. The globus pallidus interna (GPi) is selected as a target. During the DBS operation for GPi, it often passes through the boundary part of the globus pallidus inner and outer section on the trajectory when the electrode is implanted. This part contains cholinergic neurons which projects to the basal ganglia of Mynert, and it is said to be concerned with a cognitive function. In this study, we analyzed the characteristics of these cell groups and examined whether the cognitive function improves by stimulating these cell group. The average firing frequency of the cells collected was 1.2 Hz, which was lower than the firing frequency of normal pallidal cells. Although long term stimulation effect was not different in this study, it should be examined for a longer period.

Free Research Field

運動異常症