The effect of weakening the muscle by septic endotoxemia.

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K20034
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: University of Tsukuba
• Principal Investigator: Enomoto Yuki 筑波大学, 医学医療系, 講師 (30649231)
• Research Collaborator: MATSUISHI Yujiro ; SHIMOJYO Nobutake
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: ICU-AW / 敗血症 / 筋力低下 / LPS

Outline of Final Research Achievements

Sepsis model mice were created by intraperitoneal administration of lipopolysaccharide (LPS), to clarify how early rehabilitation affects the muscle weakness caused by sepsis. We measured the early survival rate, exercise ability, and metabolic ability at each stage and clarified exercise intensity of early rehabilitation intervention. We measured Carbon dioxide output (VCO 2) and oxygen output (VO 2) by using a metabolic gauge and treadmill. We revealed that twenty-four hours after LPS administration is the most severe condition, then after that turned to a recovery in this model. Besides, the low-intensity exercise, anaerobic breathing did not occur, was determined in each time zone.

Free Research Field

集中治療

Academic Significance and Societal Importance of the Research Achievements

現状では敗血症など重篤な状態に続発する筋力低下(ICU-AW)について、有効な予防・治療法は確立されておらず、早期リハビリテーションは推奨されるものの具体的な内容については確立していなかった。本研究により、敗血症に続発したICU-AWラットモデルが確立し、適切なリハビリテーション強度を確定することができた。本研究により、リハビリテーションがICU-AWの予防や早期改善に寄与するメカニズム、適切な介入開始時期、強度、方法などさらなる発展的な研究の礎となることができた。これらの詳細なメカニズムが明らかとなれば、集中治療後の患者の生活の質、医療コストの軽減など社会に与える影響は大きいと考えられる。