ACR reconstruction using PRP and beta-TCP

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K20065
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Inoue Hiroaki 京都府立医科大学, 医学(系)研究科(研究院), 助教 (60457968)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 移植腱 / 組織学的検討

Outline of Final Research Achievements

The influence of PRP on the healing process was examined histologically using a model in which the Achilles tendon is implanted in the rat femur. Achilles tendon and graft bone as a control group, β-TCP group added with β-TCP, and β-TCP + PRP group added with PRP were compared. Two weeks after surgery, the inflammatory cell infiltration was the mildest in the β-TCP + PRP group, and generally fine tendon fibers could be confirmed. Fine tendon fibers were confirmed in all groups at 4 weeks after surgery, but in the control group and the β-TCP group, dense interstitial tissue was found between the transplanted tendon and bone.

Free Research Field

膝関節

Academic Significance and Societal Importance of the Research Achievements

本研究の結果、PRPはβ‐TCPを用いた靱帯再建術において、炎症を最小限にしながら移植腱－骨癒合を促進する可能性がある。