Elucidation of the analgesic mechanism of the sigma 1 receptor in the dorsal horn of the spinal cord.

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20082
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Anesthesiology
• Research Institution: Niigata University
• Principal Investigator: Yamamoto Goh 新潟大学, 医歯学総合病院, 特任助教 (40710463)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: シグマ１受容体 / デヒドレエピアンドロステロンサルフェート / PRE-084 / 脊髄後角

Outline of Final Research Achievements

We investigated the effect of DHEAS and PRE-084, which are sigma 1 receptor agonists, on excitatory synaptic transmission in the dorsal horn neurons of the adult rat spinal cord using electrophysiological technique. We demonstrated that DHEAS enhanced excitatory transmission and suppressed inhibitory transmission in spinal lamina II neurons,resulting in showing pronociceptive effects on the spinal cord. On the other hand, PRE-084 showed no obvious effect on spinal dorsal horn neurons.

Free Research Field

麻酔