Elucidation of extracellular matrix molecular pathway regulated by metastasis-suppressing microRNAs in prostate cancer.

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20125
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Chiba University
• Principal Investigator: KATO MAYUKO 千葉大学, 医学部附属病院, 助教 (80733857)
• Co-Investigator(Renkei-kenkyūsha): ICHIKAWA TOMOHIKO 千葉大学, 大学院医学研究院, 教授 (20241953) ; SEKI NAOHIKO 千葉大学, 大学院医学研究院, 准教授 (50345013) ; KOJIMA SATOKO 帝京大学, 医学部, 准教授 (10345019) ; OKATO ATSUSHI 千葉大学, 医学部附属病院, 医員 (90756719) ; ARAI TAKAYUKI 千葉大学, 医学部附属病院, 医員 (40793055) ; KOSHIZUKA KEIICHI 千葉大学, 医学部附属病院, 医員 (00791609) ; YAMADA YASUTAKA 千葉大学, 医学部附属病院, 医員 (30814595) ; SUGAWARA SYO 千葉大学, 医学部附属病院, 医員 (70815290)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: マイクロRNA / 前立腺癌 / 細胞外マトリックス

Outline of Final Research Achievements

microRNA(miRNA) expression profile in castration-resistant prostate cancer(CRPC) revealed that miR-205-5p was reduced in CRPC tissues and that it acted as an antitumor miRNA. We focused on HMGB3 as a putative target of miR-205-5p regulation. HMGB3 was directly regulated by miR-205-5p in PCa cells and HMGB3 was overexpressed in CRPC clinical specimens.

Free Research Field

前立腺癌