2017 Fiscal Year Final Research Report
Screening for new genes for resistance to drug in prostate cancer
| Project/Area Number |
16K20136
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 癌 / 薬剤耐性メカニズム / スクリーニング |
|---|
| Outline of Final Research Achievements |
The aim of this research is to identify new genes associated with resistance to docetaxel in prostate cancer, to clarify the mechanisms. Using CRISPR/Cas9 knockout screening system, we extacted several candidate genes. We examined whether these candidate genes knockout increase docetaxel-sensitivity in prostate cancer cell line, but knockout of these genes showed no difference of sensitivity to docetaxel, comparing to control cells.
|
| Free Research Field |
泌尿器腫瘍
|
