2017 Fiscal Year Final Research Report
The mechanism of immune cells associated with prostate cancer progression
| Project/Area Number |
16K20137
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Osaka University |
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Principal Investigator |
Hayashi Takuji 大阪大学, 医学部附属病院, 医員 (50747079)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 前立腺癌 / 免疫細胞 / 高脂肪食 |
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| Outline of Final Research Achievements |
Administration of HVJ-E and anti-PD1 antibody didn't suppress prostate cancer progression of model mice.
HFD accelerated tumor growth and pro-tumor changes of local immune cells, both of which were suppressed by celecoxib. HFD-induced tumor growth was associated with IL6 signaling.
Preipheral blood monocyte count, reflecting tumor-infiltrating macrophages, is a predictive factor for adverse pathology and postoperative biochemical failure of prostate cancer patients.
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| Free Research Field |
前立腺癌
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