Investigation of the molecular network regulated by novel tumor suppressive microRNAs in bladder cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20145
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Kagoshima University
• Principal Investigator: MATSUSHITA Ryosuke 鹿児島大学, 医歯学総合研究科, 客員研究員 (80735366)
• Research Collaborator: ENOKIDA Hideki 鹿児島大学, 医歯学域医学系, 准教授 (80347103) ; YOSHINO Hirofumi 鹿児島大学, 医歯学総合研究科, 客員研究員 (90642611) ; YONEMORI Masaya 鹿児島大学, 附属病院, 医員 (00758013) ; MIYAMOTO Kazutaka 鹿児島大学, 医歯学総合研究科, 大学院生
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: マイクロRNA / 膀胱癌

Outline of Final Research Achievements

Based on the microRNAs expression profile by next generation sequencing in bladder cancer (BC), we identified several downregulated microRNAs including miR-223, miR-199 family, miR-145-5p/3p, miR-139-5p/3p, miR-26a/b-5 and found their target tumor-associated genes in BC. Finally, we found that these microRNAs may have tumor-suppressive function via direct targeting of oncogenic genes including WDR62, CCNE1/2, UHRF1, PLOD2, and ITGA3. Thus, it was revealed that several important cancer signaling pathways like cell cycle, gene’s methylation, remodeling collagens in tumor matrix, and integrin signal might be regulated by microRNA network. According to these microRNA-axis study, we obtained basic data for new therapeutic strategy by using drugs that inhibit these signaling pathways.

Free Research Field

マイクロRNA