Can the neuroendocrine cell have an effect on prostatic hypertrophy?

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20147
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Sapporo Medical University
• Principal Investigator: Kyoda Yuki 札幌医科大学, 医学部, 助教 (90718024)
• Co-Investigator(Renkei-kenkyūsha): MASUMORI Naoya 札幌医科大学, 泌尿器科学講座, 教授 (20295356)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 前立腺肥大症 / 神経内分泌細胞

Outline of Final Research Achievements

Benign prostatic hyperplasia (BPH) is a common disease that causes lower urinary tract symptoms in elderly men. However, we do not precisely know its etiology. Neuroendocrine (NE) cells may have an impact on the development of BPH.
In the prospective and retrospective study by using Spontaneously hypetensive rat, BPH model rat and human prostatic tissue, NE cells may play an important role in the initial development of BPH by paracrine fasion. And in the functional analysis of NE cells in the prostate, NE cells may have an impact on BPH through the chronic inflamation by IL-6 and so on and the pathway about appetite and obesity by leptin and melanocortin.

Free Research Field

排尿障害