2017 Fiscal Year Final Research Report
The role of regulatory T cell and related chemokines in urothelial carcinoma of the bladder
Project/Area Number |
16K20159
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Urology
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Research Institution | Nara Medical University |
Principal Investigator |
Miyake Makito 奈良県立医科大学, 医学部, 助教 (80601400)
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Keywords | 膀胱癌 / 免疫細胞 / 制御性 T 細胞 / 腫瘍関連マクロファージ / BCG 膀胱注入療法 / 骨髄由来免疫抑制細胞 |
Outline of Final Research Achievements |
The aim of this project is to evaluate the association between topical immunostatus/systemic inflammation and the risk of BCG refractory non-muscle invasive disease and metastatic muscle invasive disease. The immunohistochemical staining analysis of tumor tissue specimes with FOXP3 (Treg maker) and CD204 (TAM marker) antibodies revealed that high counts of Treg and TAM were associated with shorter recurrence-free survival and disease-free survival. The time-couse analysis of urine obtained from patients treated with intravesical BCG demonstarted that the expression of T cell makers including FOXP3 was increased with time. On the otherhand, B cell-related antigens showed much less chage compared to T cell-related antigens. We will accumulate the patients number.
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Free Research Field |
泌尿器腫瘍学
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