Functional analysis of endometrial decidualization and microRNA

2020 Fiscal Year Final Research Report

• Project/Area Number: 16K20204
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Saitama Medical University
• Principal Investigator: Tochigi Hideno 埼玉医科大学, 医学部, 非常勤講師 (90623695)
• Project Period (FY): 2016-04-01 – 2021-03-31
• Keywords: 着床不全 / 子宮内膜脱落膜化 / 習慣性流産 / マイクロRNA

Outline of Final Research Achievements

In this study, six miRNAs were identified for the important miRNAs in decidualization. It is clarified that miR-542-3p is morphologically and functionally involved in the process of endometrial decidualization by directly controlling the expression of IGFBP1. Furthermore, both of the miRNAs that miR-424 and miR-503 were collaboratively expressed that related the controlled genes by FOXO1. It was suggested that miR-424 and miR-503 clusters play an important role in the decidualization process.

Free Research Field

生殖医学

Academic Significance and Societal Importance of the Research Achievements

子宮内膜の分化過程である脱落膜化は妊娠の成立・維持に必須であり、その機能異常は着床不全、反復流産、妊娠高血圧症、子宮内胎児発育遅延などの病態の発症に深く関わっている事が広く知られている。しかし、その分化過程の分子学的なメカニズムは未解明な部分が多い。本研究の成果は、婦人科疾患の病態解明や治療標的の開発に役立てることができる。