2018 Fiscal Year Final Research Report
Establishment of a novel mouse xenograft model of human uterine leiomyoma and development of non hormonal therapy using decorin
| Project/Area Number |
16K20219
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
Suzuki Yusuke 大阪医科大学, 医学部, 非常勤医師 (90770925)
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| Research Collaborator |
Ii Masaaki
Terai Yoshito
Ohmichi Masahide
Asahi Michio
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 子宮筋腫 / 子宮筋腫移植モデル / 子宮筋腫モデルマウス / Gn-RH / エストロゲン / プロゲステロン / 子宮内膜症 / leiomyoma |
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| Outline of Final Research Achievements |
Uterine leiomyoma is the most common benign tumour in women, and an appropriate animal model for leiomyoma would be useful for exploring new therapeutic strategies. Therefore, we have been challenged to develop a new simple mouse model for human leiomyoma. As a result, this model will be useful for the development of new therapeutic strategies.
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| Free Research Field |
産婦人科
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、作製が容易で移植後も発育する新しいヒト子宮筋腫マウスモデルを確立した。このマウスモデルは、子宮筋腫に対する新しい治療法の開発に役立つと考えられる。
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