Investigation of a novel prognostic serum marker in head and neck squamous cell carcinoma

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20229
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Chiba University
• Principal Investigator: Katada Koji 千葉大学, 大学院医学研究院, 助教 (60596112)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 頭頸部癌

Outline of Final Research Achievements

We searched plectin which is expressed in head and neck cancer tissue in serum, but could not identify obvious protein or peptide with significant difference in head and neck cancer patient. However, we validated the evidence for integrin family (ITGB1) which is associated with plecitn in head and neck cancer tissues, and we found that it is controlled by microRNAs functioning as tumor suppressor genes or oncogenes. We also discovered that ITB1 is involved in the prognosis of patients with head and neck cancer and migration, proliferation and invasion of head and neck cancer cells.

Free Research Field

頭頸部癌