The involvment of HERV in lymphocyte infitration of nasopharyngeal carcinoma

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K20235
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Kanazawa University
• Principal Investigator: AGA Mitsuharu 金沢大学, 医学系, 協力研究員 (90756230)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 上咽頭癌 / LMP1

Outline of Final Research Achievements

In the present study we showed a panel of LMP1 expressing cell lines had high expression of REST compared with not. The enhancement of REST by LMP1 was regulated by activation of REST promoter, not blockade of ubiquitin-proteasome pathway. Furthermore, we demonstrated that REST works as transcriptional suppressor of CSC marker in NPC cells. Moreover, it enhances invasive potential of NPC cells. The series of findings indicate that REST functions as transcriptional repressor and involved with invasive potential of NPC expressing EBV oncogene.

Free Research Field

頭頸部癌

Academic Significance and Societal Importance of the Research Achievements

以上のことから、RESTは転写抑制因子として上咽頭癌細胞の癌幹細胞化に関わっており、上咽頭癌の浸潤能に寄与することが示唆された。以前、我々はLMP1が誘導する転写因子がエクソソームとよばれる細胞外小胞を介して周囲の細胞に運ばれることを示した。今後RESTがエクソソームを介して周囲の細胞に影響を及ぼすか検討予定である。