Prevention of age-related hearing loss through Sirt1 stabilization via MNAM

2019 Fiscal Year Final Research Report

• Project/Area Number: 16K20257
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Kumamoto University
• Principal Investigator: Kusaba Yuki 熊本大学, 病院, 非常勤診療医師 (70648592)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Keywords: 加齢性難聴 / Sirt1 / MNAM

Outline of Final Research Achievements

Age-related hearing loss was prevented in the MNAM group compared to control group.
Sirt1 expression was reduced in the control group compared to MNAM group. Sirt1 expression was prevented from the decrease in MNAM group.

Free Research Field

加齢性難聴

Academic Significance and Societal Importance of the Research Achievements

新しいSirt1安定化メカニズムを惹起する薬剤を用いて加齢性難聴を予防することを可能とした。今後、ヒトに応用されれば加齢性難聴発症を予防できる可能性がある。