2017 Fiscal Year Final Research Report
Analysis of functional relationships of dendritic cells, NKT cells, and Th17 cells in upper respiratory mucosal immunity
| Project/Area Number |
16K20259
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Oita University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | NKT細胞 / 樹状細胞 / Th17細胞 / 粘膜免疫 |
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| Outline of Final Research Achievements |
Mucosal immune responses in the nasopharynx associated with NKT cell activation were examined. Mice were administered α-galactosylceramide (α-GalCer) intranasally as a ligand for NKT cells, without any antigen.
After nasal immunization, dendritic cells (DCs) increased in nasal-associated lymphoid tissue. Antibody-producing cells, mainly those that produce immunoglobulin A, significantly increased in the nasal passage (NP).Interleukin (IL)-17-producing Th 17 cells were also induced in the NP. Bacterial challenges with live Haemophilus influenzae and Streptococcus pneumoniae resulted in enhanced clearances of both bacterial species from the nasopharynx. It is interesting that bacterial clearance was impaired by IL-17 neutralization.
These results suggest that the activation of NKT cells by nasal administration of α-GalCer induced protective immunity in the nasopharynx, possibly involving the interaction with DCs and induction of Th17 cells.
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| Free Research Field |
上気道粘膜免疫
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