2018 Fiscal Year Final Research Report
Molecular target for HPV positive HNCs
| Project/Area Number |
16K20264
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
Kondo Shunsuke 琉球大学, 医学部附属病院, 医員 (90596363)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Keywords | 頭頸部癌 / HPV |
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| Outline of Final Research Achievements |
It is still uncertain about molecular targets toward HPV positive HNCs. So we planned this study to detect a specific molecular target towards HPV positive head neck cancers (HNCs) using human cancer cell lines and also using cancer tissues.
There was a difference of gene and protein expression between HPV positive cancer cells and negative cancer cells with the component of mTOR complex 1 and 2. And we used mTOR inhibitor temsirolimus toward cancer cells. HPV positive cancer cells were more efective with temsirolimus. Also we extract cDNA from Oropharyngeal cancer tissues and investigate the gene expression of the component of mTOR complex 1 and 2. The result of tissue was similar with the result of cancer cells. With the result of this study mTOR seemed to be an important target toward HPV positive HNCs.
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| Free Research Field |
耳鼻咽喉科
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| Academic Significance and Societal Importance of the Research Achievements |
咽頭癌、特に中咽頭（扁桃）癌においてヒトパピローマウィルス（HPV)が発症に関与することは広く知られている。またHPVによる癌の発症機序は喫煙やアルコールが関連する癌の発症機序と異なる。しかしHPVが関与する癌に関して特異的な治療はまだ見つかっていない。そこで本研究にてHPVに特化した標的分子の検討を行った。結果として、細胞の増殖や細胞死に関連するmTORがHPV関連癌において重要な標的分子であることが示された。HPV関連癌に関して新たな治療の可能性が示唆された。
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