Evaluation of non-swelling hydrogel as a intraocular tamponade during vitrectomy for retinal detachment

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20303
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: University of Tsukuba
• Principal Investigator: Hoshi Sujin 筑波大学, 医学医療系, 講師 (10757892)
• Research Collaborator: OKAMOTO Fumiki 筑波大学, 医学医療系, 講師 (30334064) ; SAKAI Takamasa 東京大学, 大学院・工学系研究科 バイオエンジニアリング専攻, 准教授 (70456151)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 眼内タンポナーデ / 人工硝子体 / 眼毒性 / ハイドロゲル / 分解性

Outline of Final Research Achievements

We conducted experiments to test intraocular toxicity of non-swelling hydrogel as a intraocular tamponade using rabbit eyes. There was limited postoperative inflammatory response, no intraocular pressue elevation or sign of hydrogel opacity. Retinal microstructure and retinal function was normal. We concluded that this hydrogel could be used safely as a intraocular tamponade. The material we used, however, was non-degradable hydrogel. To establish a sutable material for clinical use, we continue our research to fabricate degradable non-swelling hydrogel and evaluate its safety and feasibility as a intraocular tamponade.

Free Research Field

眼科