Tissue Plasminogen Activator as an Antiangiogenic Agent in Experimental Laser-induced Choroidal Neovascular ization in Mice

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20323
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Nagoya City University
• Principal Investigator: Mizutani Takeshi 名古屋市立大学, 大学院医学研究科, 助教 (70770428)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 脈絡膜新生血管 / プラスミノーゲン活性化因子 / CNV / ｔPA

Outline of Final Research Achievements

We investigate the antiangiogenic efficacy of tissue plasminogen activator (tPA) on experimental laser-induced choroidal neovascularization (CNV) in mice. Intravitreal administration of tPA significantly suppressed CNV leakage and CNV volume. Intravitreal injection of tPA suppressed fibrin/fibrinogen and CD31 expression in laser-induced lesions. Histologic examination and electroretinography showed no evidence of retinal toxicy in eyes injected with tPA. The current results suggested that tPA may be a potential therapeutic adjuvant for treating CNV.

Free Research Field

脈絡膜新生血管