2017 Fiscal Year Final Research Report
Pathogenesis of age-related macular degeneration related to high fat diet
| Project/Area Number |
16K20330
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
Tomita Yohei 慶應義塾大学, 医学部(信濃町), 特任助教 (00528200)
|
|---|
| Research Collaborator |
OZAWA Yoko
TODA Eriko
NAGAI Norihiro
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 高脂肪食 / 網膜 / 加齢 |
|---|
| Outline of Final Research Achievements |
Five-week old male mice were constantly fed either with high fat diet (including 32% fat) or control diet (including 4.6% fat), both of which were commercially available. The body weight and blood sugar levels of the high fat diet-fed mice were increased compared with control diet-fed mice after 3 months, although the animals did not have diabetes. The inflammatory cytokines and macrophage markers were increased in the RPE-choroid samples of the high fat diet-fed mice compared with control diet-fed mice.
|
| Free Research Field |
眼科学
|
