2017 Fiscal Year Final Research Report
protective effect for retinal ganglion cell
| Project/Area Number |
16K20341
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
AKIYAMA Goichi 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 研究員 (00529547)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 緑内障 / 神経保護 / エダラボン |
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| Outline of Final Research Achievements |
We invastigated that intraocular injection of edaravone exerts neuroprotective effects in an ONI model.Sequential in vivo retinal imaging revealed that post-ONI treatment with edaravone was effective for maintaining the retinal structure. We also demonstrated that edaravone suppressed the production of ROS and stress-induced ASK1-p38 MAPK signaling, which leads to RGC survival following ONI（Akiyama et al. IOVS, 2017）.
We also investigated that the effect of ocular hypertension in human surgical procedure（Akiyama et al. Sci Rep, 2016).
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| Free Research Field |
緑内障
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