The contribution of melanocytes and interaction with fibroblasts to wound healing of skin

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20356
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Osaka University
• Principal Investigator: Maeda Daisuke 大阪大学, 医学部附属病院, 医員 (60772465)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: メラノサイト / 線維芽細胞

Outline of Final Research Achievements

It is common that keloids and hypertrophic scars occur to colored races. In other words, the races with strong activity of melanocytes tend to produce abnormal scars. In addition, keloids and hypertrophic scars are rarely produced in colored races at sites where the weak activity of melanocytes such as palms and soles. Therefore, we considered the possibility that melanocytes are involved in the formation of keloids and hypertrophic scars.
Melanocytes from black race or white race and skin normal fibroblasts were cocultured and we analyzed differentiation into myofibroblasts by using western blot, but no significant difference was observed. Also, when trying primary culture of plantar origin melanocytes, there are few cells that can be harvested and we did not compare samples between plantar and trunk.

Free Research Field

形成外科