Analysis of anti-inflammatory effect of recombinant thrombomodulin for severe sepsis

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20381
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Gifu University
• Principal Investigator: Suzuki Kodai 岐阜大学, 医学部附属病院, 助教 (80724583)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 敗血症 / 多臓器不全 / リコンビナントトロンボモジュリン

Outline of Final Research Achievements

Multiple organ failure often occurs in sepsis via vascular endothelial injuries. It was recently reported that recombinant thrombomodulin (rTM) had anti-inflammatory and anticoagulant effects in sepsis. As a result, rTM-treated mice were significantly decreased mortality and each organ failures including heart, lung, liver and kidney compared with LPS-treated mice. In septic mice, endothelial wall became destroyed and endothelial glycocalyx was peeled away. On the other hands, rTM therapy attenuated endothelial injuries and endothelial glycocalyx injuries. These results demonstrated that rTM attenuates LPS-induced sepsis caused microvascular injuries and increases survival rate.

Free Research Field

救急医学