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2017 Fiscal Year Final Research Report

Analysis of anti-inflammatory effect of recombinant thrombomodulin for severe sepsis

Research Project

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Project/Area Number 16K20381
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionGifu University

Principal Investigator

Suzuki Kodai  岐阜大学, 医学部附属病院, 助教 (80724583)

Project Period (FY) 2016-04-01 – 2018-03-31
Keywords敗血症 / 多臓器不全 / リコンビナントトロンボモジュリン
Outline of Final Research Achievements

Multiple organ failure often occurs in sepsis via vascular endothelial injuries. It was recently reported that recombinant thrombomodulin (rTM) had anti-inflammatory and anticoagulant effects in sepsis. As a result, rTM-treated mice were significantly decreased mortality and each organ failures including heart, lung, liver and kidney compared with LPS-treated mice. In septic mice, endothelial wall became destroyed and endothelial glycocalyx was peeled away. On the other hands, rTM therapy attenuated endothelial injuries and endothelial glycocalyx injuries. These results demonstrated that rTM attenuates LPS-induced sepsis caused microvascular injuries and increases survival rate.

Free Research Field

救急医学

URL: 

Published: 2019-03-29  

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