2017 Fiscal Year Final Research Report
Functional analysis of nectins in mouse submandibular glands
| Project/Area Number |
16K20411
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kobe University |
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Principal Investigator |
KITAYAMA MIDORI (吉田) 神戸大学, 医学部附属病院, 医員 (20636427)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | nectin / submandibular gland |
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| Outline of Final Research Achievements |
The epithelial cells are linked to each other by cell adhesion molecules that form cell-cell junctions,such as adherens junction(AJ) and tight junction(TJ).The abnormalities of the AJ and TJ components in the salivary gland are associated with the onset of inflammatory diseases or histological abnormalities.We investigated the expression and localization of AJ and TJ components,especially focusing on the localization and roles of nectin family members.The AJ components were located at the apical portion of the boundary between neighboring striated duct cells.Although N1KO submandibular glands were morphologically diminished,There is no significant alteration of the localization of AJs and TJs molecules.The expression level of amylase in the N1KO submandibular glands was lower than that of WT.The serum levels of thyroid hormone thyroxin(T4) were not different between WT and N1KO.Our results suggest that nectins are involved in the maintenance and development of the salivary glands.
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| Free Research Field |
歯科口腔外科
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