Analysis of novel pathogenic mechanism of aggressive periodontitis by oral bacteria

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K20415
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Morphological basic dentistry
• Research Institution: Beppu University (2018); Matsumoto Dental University (2016-2017)
• Principal Investigator: SHIOYA KOKI 別府大学, 公私立大学の部局等, 講師 (40727632)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 侵襲性歯周炎 / ロイコトキシン / 骨吸収 / 病原因子

Outline of Final Research Achievements

Gram-negative bacteria Aggregatibacter actinomycetemcomitans (Aa) are involved in aggressive periodontitis in adolescents of African descent, and in particular leucotoxin (Ltx) highly producing strain Aa JP2 strain has been isolated. In this study, LtxA affects osteoclast differentiation that affects bone resorption. However, the ability to differentiate was very weak, suggesting that LtxA co-work with other pathogen factor such as LPS.

Free Research Field

微生物学

Academic Significance and Societal Importance of the Research Achievements

侵襲性歯周炎の有効な治療法はなく、新たな治療薬の開発は急務であった。本実験でLtxAが骨吸収に影響することが示唆されたため、LtxAをターゲットにした創薬に繋がることが期待される。また、この知見は通常の歯周炎の発症メカニズム解明にも役立つことが期待される。