2017 Fiscal Year Final Research Report
Research on mechanism of periodontitis exacerbation via regulation of T cell differentiation by hypoxia signal
| Project/Area Number |
16K20416
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
Horibe Kanji 松本歯科大学, 歯学部, 助教 (70733509)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 歯学 / 歯周病 / 免疫細胞 / サイトカイン |
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| Outline of Final Research Achievements |
In this study, we focused on the relationship between hypoxia-inducing factor (HIF) and inflammatory cytokines IL-17 and Th17 in the onset and deterioration of periodontitis.
The experiment was carried out by adopting a model that induces the occurrence of periodontitis by ligating the silk thread to the molar of the upper jaw of the mouse. We examined the localization of HIF, IL-17, T cells immunohistologically on the periodontal tissue in which alveolar bone destruction occurred, but no clear difference was found compared with healthy periodontal tissue. Gene expression of IL-17 in periodontitis showed an upward trend in real time PCR. There was no difference in the amount of alveolar bone destruction in IL-17A and IL-17F gene-deficient and wild-type mice, respectively.
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| Free Research Field |
組織学
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