Role of salivary gland blood flow increase caused by trigeminal autonomic reflex: A new approach to salivary secretion disorder

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20425
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Functional basic dentistry
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: Sato Toshiya 北海道医療大学, 歯学部, 講師 (30709241)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 唾液腺 / 血流動態 / 副交感神経 / 唾液分泌

Outline of Final Research Achievements

The aim of this study is to clarify the role of parasympathetic blood flow increase in salivary glands in salivary secretion. Experiments using rats showed that the glandular blood flow increase caused by the stimulation of the lingual nerve (LN) was larger in the submandibular gland (SMG) and sublingual gland (SLG) than in the parotid gland (PG), and significant salivary secretion was observed from the SMG / SLG. The glandular blood flow increase caused by the LN stimulation was inhibited approximately 60 to 70% by NO synthase inhibitor. Further, mixed saliva from SMG / SLG and saliva form PG were inhibited approximately 33% and 73%, respectively. Therefore, it was suggested that glandular blood flow increase corresponding to secretory activity was induced in reflex salivary secretion, and salivary secretion and glandular blood flow increase were coordinately regulated. It was also thought that the glandular blood flow increase is extremely important in salivation.

Free Research Field

口腔生理学