2017 Fiscal Year Final Research Report
Analysis of promoting in vitro multispecies biofilm formation by stress response with antimicrobial component
| Project/Area Number |
16K20451
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Conservative dentistry
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | バイオフィルム / ストレス応答 / Calgary Biofilm Device / 共焦点レーザー顕微鏡 / 複合バイオフィルムモデル / 化学的制御 / バイオフィルム形成関連遺伝子 |
|---|
| Outline of Final Research Achievements |
In this study, we investigated the mechanism of biofilm formation promotion by stress response under the action of low concentration antimicrobial component using in vitro complex biofilm model. After the action of chlorhexidine gluconate (CHG) below the minimum inhibitory concentration (sub-MIC), an increase in the amount of biofilm was observed but no increase in viable count was observed, so that the amount of matrix increased It was inferred. It was suggested that CHG of sub-MIC promotes biofilm formation by influencing the production of extracellular matrix, not bacterial growth in biofilm.
|
| Free Research Field |
保存治療系歯学
|
