2017 Fiscal Year Final Research Report
Establishment of the next-generation intentional replantation by using of Wnt5a signaling-induced effective periodontal ligament tissue regeneration
| Project/Area Number |
16K20458
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 歯根膜 / Wnt5a / Ror2 / JNK / コラーゲン線維形成促進 / 石灰化抑制 |
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| Outline of Final Research Achievements |
In this study, it was revealed that Wnt5a acts on promoting the collagen-formation and suppression of the calcification in human periodontal ligament（PDL）cells via Ror2 and JNK. It was also shown that Ror2 is highly expressed in human PDL cell line with high expression of PDL-related markers. These results suggest that Wnt5a/Ror2/JNK signaling is involved in the mechanism by which PDL tissue maintains fibrous connective tissue without calcification.
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| Free Research Field |
医歯薬学
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