2017 Fiscal Year Final Research Report
Fabrication of nobel bone grafting material with soft tissue healing enhancement
| Project/Area Number |
16K20507
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 骨補填材料 |
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| Outline of Final Research Achievements |
In recent years, researchers have developed and fabricated synthetic bone substitutes to achieve a high relative amount of new bone, while avoiding or minimizing the risks of invasive harvesting of bone from a healthy site, disease transmission and antigenicity. The mechanism of action of materials used for bone regeneration is osteoconduction, which provides a scaffold for enhanced bone tissue growth and formation. A promising technique to increase the bioactivity of carbonate apatite blocks is the addition of osteoinductive growth factors or drugs incorporated into the composite. Statin, a cholesterol-lowering drug, has been shown to have positive effects on bone formation. Additionally, solutions of statin in optimal concentrations could be combined with bone grafts to enhance their regenerative potential.
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| Free Research Field |
歯科補綴学
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