2017 Fiscal Year Final Research Report
Establishment of a new method for regeneration of hard tissue using stem cells
| Project/Area Number |
16K20543
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 骨 / BMP / LPS / IL-1 / TGF / 破骨細胞 |
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| Outline of Final Research Achievements |
BMP (bone morphogenetic protein) induces ectopic bone formation when it was implanted into the muscle tissues. We found that TGF strongly enhances ectopic bone formation by BMP-2, while LPS inhibits it. From the analysis data, TGF increased the number of osteoblasts and chondrocytes but reduced the number of osteoclasts. On the other hand, LPS reduced the ectopic bone volume less than 50%, but it was failed in IL-1 deficient mice. In addition, IL-1 inhibited the proliferation of the cells obtained from the ectopic bone, suggesting that LPS suppresses ectopic bone formation via IL-1.
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| Free Research Field |
歯科補綴学
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