2017 Fiscal Year Final Research Report
Chemotherapy induces phenotypic alterations of tumor cells that facilitate antitumor T cell responses in a mouse model of oral cancer
| Project/Area Number |
16K20563
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 免疫化学療法 |
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| Outline of Final Research Achievements |
In the present study, we investigated the antitumor effects of chemotherapy using a mouse oral cancer model using immunological analyses. We examined apoptotic cell death of tumor cells with chemotherapy both in vitro and in vivo. We also investigated whether in vivo administration of chemotherapy affected the distributions of immune cells in tumor-bearing mice. Chemotherapy induced significant oral cancer-cell apoptosis in vitro, and in vivo chemotherapy markedly attenuated established mouse tumor growth. In vivo chemotherapy decreased the numbers of both myeloid-derived suppressor cells (MDSCs) and B cells in tumor-bearing mice. Moreover, chemotherapy upregulated tumor-cell surface expressions of several immune accessory molecules and adhesion molecules, including CD80, CD86, CD40, ICAM-1, VCAM-1, and P-selectin. These results suggest that chemotherapy can induce host antitumor immune responses, which would facilitate antitumor effects in the treatment of oral cancer.
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| Free Research Field |
口腔がん
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