2017 Fiscal Year Final Research Report
Expression and function of serum Exosoomal miRNA in oral squamous cell carcinoma
| Project/Area Number |
16K20582
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Ehime University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 口腔扁平上皮癌患 / Exosome / バイオマーカー |
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| Outline of Final Research Achievements |
We performed the microRNA (miRNA) array analysis using serum exosome miRNAs obtained from oral squamous cell carcinoma (OSCC) patients and healthy volunteers. As a result, we found that 33 miRNAs were significantly up-regulated and 15 miRNAs were down-regulated more than 3-fold changes in OSCC patients compared to healthy volunteers. Among these miRNAs, exosome miR-6068 was the most up-regulated in OSCC patients. And exosome miR-6068 in the culture medium of OSCC cells also increased. We identified exosome miR-26a as a down-regulated miRNA in OSCC patients. In addition, the expression of miR-26a was also significantly decreased in whole serum and OSCC tissues. Furthermore, miR-26a significantly inhibited the growth of human OSCC cells. These results suggest that miR-26a has potential as a novel biomarker and therapeutic tool for OSCC patients.
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| Free Research Field |
口腔癌
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