Development of a novel treatment for peripheral neuropathy using dental pulp stem cell-derived exosome

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20601
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Adachi Tetsuya 京都府立医科大学, 医学(系)研究科(研究院), 助教 (10613573)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: エクソソーム / 歯髄幹細胞 / 末梢神経障害 / 間葉系幹細胞

Outline of Final Research Achievements

Treatment of peripheral neuropathy, a complication of surgery in the field of oral surgery, has not yet been established. In recent years, exosomes secreted from cells encapsulate nucleic acids and proteins and are involved in various biological phenomena, so they attract much attention in many research fields. Among them, it has been reported that exosome (DP-Exo) derived from dental pulp stem cells has an anti-inflammatory effect and the like. We aim to develop a novel drug delivery system for peripheral neuropathy by using this DP-Exo and nanocarrier in combination.

Free Research Field

生体材料学