Search for novel marker for defining microenvironment of metastasis of oral cancer

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K20602
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Nara Medical University
• Principal Investigator: Kurihara MIyako 奈良県立医科大学, 医学部附属病院, 研究員 (40453170)
• Research Collaborator: Sasahira Tomonori
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 口腔癌 / 転移 / 微小環境

Outline of Final Research Achievements

We found PAUF and ZFAND4 for defining microenvironment of oral cancer. PAUF expression was significantly assocoated with nodal metastasis and poor prognosis of oral cancer. PAUF was also involved in acquisition of proliferation and invasion ability and cisplatin resistance in oral cancer cells.
Furthermore, expression of ZFAND4 was strongly related to nodal and distant metastasis of oral cancer. Cases with high expression of ZFAND4 had a significantly unfavourable prognosis compared with patients with low expression of ZFAND4. Moreover, ZFAND4 overexpression was an independent poor prognostic factor for oral cancer as determined by multivariate analysis.

Free Research Field

口腔外科学

Academic Significance and Societal Importance of the Research Achievements

PAUFとZFAND4の機能を抑制することでがんにとって好ましい微小環境を破壊できる可能性があり、口腔癌の診断・治療におけるあらたな分子標的となることが期待される。