Analysis of metabolic changes associated with cetuximab resistance in oral squamous cell carcinoma and designing of new treatment

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K20613
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Keio University
• Principal Investigator: Yoshikawa Momoko 慶應義塾大学, 医学部(信濃町), 訪問研究員 (50570967)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: CD44v / 口腔扁平上皮癌 / セツキシマブ

Outline of Final Research Achievements

Our group established cetuximab-resistant cells by using oral squamous cell carcinoma cells expressing CD44v, which is cancer stem cell marker. We also found that cetuximab-resistant cells had high activity of metabolic pathways different from those of the original cell strain by metabolic analysis. We continue to analyze at the molecular level of the metabolic changes associated with cetuximab resistance, and aim at developing new treatments for cetuximab refractory cases.

Free Research Field

口腔癌

Academic Significance and Societal Importance of the Research Achievements

セツキシマブ耐性化に伴う分子機構の解析を行うことで、セツキシマブ不応症例に対する新規治療法の開発および患者個別の治療法の可能性も示唆された。