Research and clinically apply of novel personalized treatment biomarkers for oral cancer using tissue microarray

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K20617
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Tokyo Metropolitan Tama Medical Center (Department of Clinical Research)
• Principal Investigator: Watabe Yukio 東京都立多摩総合医療センター(臨床研究・教育研修センター(臨床研究部)), 歯科口腔外科, 医員 (50733490)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 口腔がん / 組織マイクロアレイ / アクチン関連たんぱく質

Outline of Final Research Achievements

Here we assessed expression of actinin-4, which has been implicated in cancer invasion and metastasis, to investigate whether actinin-4 may serve as a prognostic indicator We investigated their clinical factors, immunohistochemically stained tumor samples for actinin-4, and performed association analysis. Actinin-4 expression was positively correlated with delayed cervical lymph node metastasis. Disease-free survival was significantly lower in patients who were positive for actinin-4 expression. Actinin-4 was an independent prognostic factor for disease-free survival in oral squamous cell carcinoma.

Free Research Field

口腔がん

Academic Significance and Societal Importance of the Research Achievements

口腔癌組織マイクロアレイを用いて免疫染色をおこない後発頸部リンパ節転移に関与するバイオマーカーを抽出した。免疫染色は実臨床でもおこなわれている検査方法である。手術検体を用いて後発頸部リンパ節転移の予測をすることにより頸部郭清や術後補助療法の実施の根拠となり得る。個別化治療を推進していく上で意義のある研究成果が得られた。