2017 Fiscal Year Final Research Report
Identification of cervical lymph node metastasis prediction molecular marker of oral squamous cell carcinoma from saliva
| Project/Area Number |
16K20618
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 口腔扁平上皮癌 / メタボローム / 頸部リンパ節転移 / 唾液 |
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| Outline of Final Research Achievements |
The detection of cervical lymph node metastasis is important to a prognostic value. Improvement of the diagnosis precision requires a reliable marker. 25 metabolite showed a statistically significant difference between two groups of the oral patients with squamous cell carcinoma and healthy subject among 499 ionic metabolite as a result that oral patients with squamous cell carcinoma 22 case, healthy subject 21 received metabolic analysis using the saliva. Choline, p-Hydroxyphenylacetic acid, 3-Hydroxybutyric acid was a patient with oral squamous cell carcinoma, and Urea was in particular high level in healthy subjects.3-Hydroxybutyric acid was the metabolite that a past did not have the report for oral squamous cell carcinoma.
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| Free Research Field |
口腔外科
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