Analysis of the response mechanism of Runx 2 in tooth movement delay in cleidocranial dysplasia

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20638
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Tohoku University
• Principal Investigator: BANDO Kanan 東北大学, 大学病院, 医員 (20772198)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 鎖骨頭蓋異形成症 / Runx2

Outline of Final Research Achievements

Runx2 is an essential transcription factor for osteoblast and chondrocyte differentiation necessary for osteogenesis and is known as a causative gene for cleidocranial dysplasia. The Runx2 hetero knockout mouse, which is a model of the cleidocranial dysplasia, may have a decreased mechanical stress response and a decreased promotion of osteoblast cell differentiation. Therefore, in this study, experimental teeth were moved to Runx2 hetero knockout mice and related factors around the teeth were examined. In Runx2 hetero knockout mice, not only the distance of tooth movement but also the reduction of inflammatory cytokines and cell infiltration was observed.

Free Research Field

医師薬学