Analyzing of microbiome of a poor understanding group 'Ktedonobacteria' with Actinomycetes-Like Morphology and exploration of new bioactive compounds from the group.

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20903
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied microbiology; Natural medicines
• Research Institution: Tohoku University
• Principal Investigator: Yabe Shuhei 東北大学, 農学研究科, 准教授 (60564838)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: クテドノバクテリア / 二次代謝産物

Outline of Final Research Achievements

We have research on Ktedonobacteria based on a point of view that they have the potential to become a new sustainable source from which new and improved drugs can be produced, as has historically been the case with actinomycetes. As results of this study, it was revealed that Ktedonobacteria lives diversely at low abundances in common environments. And we were succeeded in isolating several diverse ktedonobacterial strains from various environments using selective medium that we developed, and we are proposing them as two new genera and six novel species in the family Ktedonobacteria. Furthermore, unique anthraquinone compounds having anti-MRSA activity was found from culture liquid extracts of the ktedonobacterial strains.
The exploitation of this group can create new developments in the field of natural products exploration by the traditional methods and may contribute to the prevention of spread of infectious diseases.

Free Research Field

応用微生物学