2017 Fiscal Year Final Research Report
Elucidation of the mechanism of radioresistance in cancer cells using trans-omics approach and development of clinical biomarkers for radiotherapy.
| Project/Area Number |
16K20909
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
Medical Physics and Radiological Technology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Research Collaborator |
TOMIOKA Yoshihisa 東北大学, 大学院薬学研究科, 教授 (00282062)
MATSUMOTO Yotato 東北大学, 大学院薬学研究科, 講師 (90420041)
TSUKAMOTO Hiroki 東北大学, 大学院薬学研究科, 助教 (70423605)
FUKUMOTO Manabu 東京医科大学, 医学部, 特任教授 (60156809)
KUWAHARA Yoshikazu 東北医科薬科大学, 医学部, 准教授 (00392225)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 放射線耐性 / プロテオミクス / メタボロミクス / 脂肪酸合成酵素 / がん細胞 |
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| Outline of Final Research Achievements |
In this study, we aimed to identify the molecules involved in radioresistance of cancer cells and to elucidate its mechanism. Here, we quantitatively compared the proteomes and the metabolomes of clinically relevant radioresistant (CRR) cell lines and their parent strains. In CRR cells, the chaperones and the proteins involved in oxidative stress were higher than control cell lines. Pathways such as amino acid metabolism and fatty acid metabolism were found to be highly enriched in CRR cells. These molecules can be expected as radiation tolerance markers and/or new targets for cancer therapies.
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| Free Research Field |
医療薬学
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