2017 Fiscal Year Final Research Report
Neural basis for pathway-selective activation of amygdala
Project/Area Number |
16K20963
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Neurophysiology / General neuroscience
Nerve anatomy/Neuropathology
|
Research Institution | The University of Tokyo |
Principal Investigator |
Miyamichi Kazunari 東京大学, 大学院農学生命科学研究科(農学部), 特任准教授 (30612577)
|
Research Collaborator |
Ishii Kentaro 東京大学, 大学院農学生命科学研究科, 大学院生
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Keywords | 性的二形 / 神経回路 / フェロモン / 性行動 / 視床下部 / 扁桃体 |
Outline of Final Research Achievements |
In mice, chemosensory signals derived from mates or predators evoke stereotyped behavioral responses such as sexual or defensive behaviors. How a specific sensory input is converted to a stereotyped behavioral output remained elusive. In this study, we mapped responsible neural circuit for enhanced sexual behaviors of adult female mice induced by a male-specific sex pheromone called ESP1. In the medial amygdala, ESP1 activated distinct projection neurons depending on the sex of recipient mice. In hypothalamus, ESP1 and a predator’s signal (snake skin) were mediated by mostly non-overlapping neurons that were intermingled in the same brain region. Together, these data revealed the presence of labeled-line organization for processing the sensory signals that evokes innate behavioral outputs.
|
Free Research Field |
神経科学
|