2018 Fiscal Year Final Research Report
The role of cell adhesion molecule 1 (CADM1) on the high-grade neuroendocrine carcinoma of the lung
Project/Area Number |
16K20993
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Human pathology
Experimental pathology
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Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2018) The University of Tokyo (2016-2017) |
Principal Investigator |
Tanei Zen-ichi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (90757650)
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Keywords | CADM1 / 細胞接着分子 / 肺神経内分泌癌 / 転移 |
Outline of Final Research Achievements |
High-grade neuroendocrine carcinoma of the lung, such as small cell carcinoma or large cell neuroendocrine carcinoma, is a cancer with a poor prognosis that causes lymph node metastases or distant metastases at an early pathological stage. Cell Adhesion Molecule 1 (CADM1) was identified as a tumor suppressor gene in non-small cell lung cancer, and its expression is decreased in advanced cancers of various organs. CADM1, however, serves as an oncogene in adult T-cell leukemia and therefore has conflicting functions. In this study, we clarified the possibility of CADM1 playing an oncogene in lung high-grade neuroendocrine cancer from clinicopathological analyses and experimental models.
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Free Research Field |
神経病理学
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Academic Significance and Societal Importance of the Research Achievements |
本研究では,手術検体を用いて,免疫組織化学的に CADM1 が肺高悪性度神経内分泌癌に高率に発現し,予後不良因子であることを初めて明らかにした.また,実験モデルの作製に成功した.今後,肺高悪性度神経内分泌癌における CADM1 の機能の詳細な解明や診断,治療法の開発につながると考えられる.
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