2017 Fiscal Year Final Research Report
Identification of a novel anti-mycobacterial agent in human serum
| Project/Area Number |
16K21044
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including mycology)
Infectious disease medicine
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| Research Institution | Osaka City University (2017)
Niigata University (2016) |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 高齢者結核 |
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| Outline of Final Research Achievements |
In the presence of human serum, Mycobacterium tuberculsis and BCG cannot grow. In this study, we try to explore a novel anti-mycobacterial agent in human serum, which may suppress mycobacterial growth in healthy persons. We first expected that the exosomes in serum might be involved in this phenomenon, but serum exosomes did not have anti-mycobacterial effect. Rather, exosome-depleted serum could suppress mycobacterial growth. Anti-mycobacterial activity of exosome-depleted serum may be brought by anti-bacterial peptide, such as cathelicidin or defensin, and further examination is required.
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| Free Research Field |
細菌学
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