Elucidation of transportation mechanism of NAD precursors

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K21051
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General medical chemistry; Eating habits
• Research Institution: University of Toyama
• Principal Investigator: Yaku Keisuke 富山大学, 大学院医学薬学研究部(医学), 研究員 (70761865)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: NAD / 代謝 / メタボロミクス

Outline of Final Research Achievements

In this project, we tried to elucidate the transportation mechanism of NAD precursors which are expected to have beneficial effects on lifestyle diseases. To measure NAD metabolites all at once, we developed NAD metabolomics by combining HPLC and mass spectrometry. By using the methods, we found that NR, which is one of the major NAD precursors, was metabolized via novel pathway distinct from classical route.

Free Research Field

代謝