2017 Fiscal Year Final Research Report
Establishment of a new electrophysiological tool for evaluating small fiber dysfunction
Project/Area Number |
16K21068
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Neurology
Laboratory medicine
|
Research Institution | Shinshu University |
Principal Investigator |
Kodaira Minori 信州大学, 学術研究院医学系(医学部附属病院), 助教 (60648012)
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Keywords | 末梢神経障害 / 痛覚 / 痛覚関連脳電位 |
Outline of Final Research Achievements |
We investigated clinical utility of intraepidermal electrical stimulation (IES) for evaluating small fiber (A-delta fiber) dysfunction. In patients with transthyretin familial amyloid polyneuropathy (ATTR-FAP) and healthy subjects, we evaluated pain threshold using IES and cold threshold using quantitative sensory testing (QST). Pain-related evoked potentials using IES were also analyzed. Pain threshold using IES was correlated with cold threshold using QST. Amplitude of pain-related evoked potentials was decreased with small fiber dysfunction in patients with ATTR-FAP. IES has a potential for a new clinical tool to evaluate small fiber dysfunction.
|
Free Research Field |
神経生理学
|