IL33/ST2 pathway involvement in the pathogenesis and disease progression of primary biliary cholangitis

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K21069
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology; Immunology
• Research Institution: Shinshu University
• Principal Investigator: JOSHITA SATORU 信州大学, 学術研究院医学系, 助教 (90597965)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 原発性胆汁性胆管炎 / IL-33 / ST2 / Autotaxin

Outline of Final Research Achievements

Primary biliary cholangitis (PBC) is a slowly progressive liver-specific autoimmune disease. The pathogenesis and mechanism of PBC progression are incompletely understood. The key findings of this study were as follows; 1) the IL33/ST2 pathway was associated not only with pathogenesis, but also with disease progression, in patients with PBC. 2) Serum Autotaxin values appear to be useful for assessing disease stage and prognosis in PBC.

Free Research Field

肝臓病学