2017 Fiscal Year Final Research Report
Mechanism of the regulation of epithelial function by hydrostatic pressure and the application for canter treatment
| Project/Area Number |
16K21101
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Tumor biology
General physiology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | タイトジャンクション / 浸透圧 / アクチン / クローディン |
|---|
| Outline of Final Research Achievements |
In this study, I attempted to elucidate the mechanism of the regulation of epithelial functions by the extracellular environment.
In MDCK cells, I revealed that claudin-2, transmembrane proteins in tight junctions, act as the sensor of the osmotic gradient between apical and basal sides to regulate several cell functions including transepithelial transport and cytoskeleton. Furthermore, I succeeded in establishing claudin-2 and claudin-4 double knockout cells and revealed the physiological role of claudin-4.
This study elucidates the mechanism in the epithelial cells to sense extracellular environment and regulate cell functions. This study also contributes to set a foundation for the clinical application for the cancer therapy in the future.
|
| Free Research Field |
呼吸器内科
|
